Drug interactions
Hyoscyamine + Ipratropium
Severity: Moderate
Hyoscyamine and Ipratropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine is a systemic antimuscarinic that can add to the anticholinergic effects of ipratropium, such as dry mouth, constipation, urinary retention and tachycardia. Inhaled ipratropium is poorly absorbed, so the additive effect is usually modest.
What this interaction means in plain words
Hyoscyamine and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hyoscyamine belongs to Genitourinary; Ipratropium belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for urinary retention, constipation and heart rate changes, especially in older adults. Reduce the hyoscyamine dose if anticholinergic symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Hyoscyamine with Ipratropium?
MediHelp rates the interaction as moderate. Hyoscyamine and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine is a systemic antimuscarinic that can add to the anticholinergic effects of ipratropium, such as dry mouth, constipation, urinary retention and tachycardia. Inhaled ipratropium is poorly absorbed, so the additive effect is usually modest.
How serious is the interaction between Hyoscyamine and Ipratropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and heart rate changes, especially in older adults. Reduce the hyoscyamine dose if anticholinergic symptoms appear.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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