Drug interactions
Hyoscyamine + Succinylcholine
Severity: Minor
Hyoscyamine and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine is an antimuscarinic that opposes succinylcholine's muscarinic effects, such as bradycardia and increased secretions. It has little effect on the neuromuscular blockade itself, and the combination is usually well tolerated.
What this interaction means in plain words
Hyoscyamine and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hyoscyamine belongs to Genitourinary; Succinylcholine belongs to Musculoskeletal.
Why it happens
Muscarinic receptor blockade counteracts the muscarinic effects of succinylcholine, with no important effect on nicotinic transmission.
What to do
No dose change is needed. Monitor heart rate and watch for additive anticholinergic effects such as tachycardia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Succinylcholine
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Hyoscyamine with Succinylcholine?
MediHelp rates the interaction as minor. Hyoscyamine and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hyoscyamine is an antimuscarinic that opposes succinylcholine's muscarinic effects, such as bradycardia and increased secretions. It has little effect on the neuromuscular blockade itself, and the combination is usually well tolerated.
How serious is the interaction between Hyoscyamine and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor heart rate and watch for additive anticholinergic effects such as tachycardia.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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