Drug interactions
Ibutilide + Leuprolide
Severity: Major
Ibutilide and Leuprolide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide has a high risk of torsades de pointes, and leuprolide may add QT prolongation. The pairing increases the chance of life-threatening ventricular arrhythmia.
What this interaction means in plain words
Ibutilide and Leuprolide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ibutilide belongs to Cardiovascular; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation: ibutilide blocks IKr and androgen deprivation may prolong repolarization.
What to do
Use continuous ECG monitoring during and after ibutilide administration, and ensure normal potassium and magnesium. Avoid ibutilide if the baseline QTc is prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Leuprolide?
MediHelp rates the interaction as major. Ibutilide and Leuprolide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibutilide has a high risk of torsades de pointes, and leuprolide may add QT prolongation. The pairing increases the chance of life-threatening ventricular arrhythmia.
How serious is the interaction between Ibutilide and Leuprolide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use continuous ECG monitoring during and after ibutilide administration, and ensure normal potassium and magnesium. Avoid ibutilide if the baseline QTc is prolonged.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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