Drug interactions
Ibutilide + Posaconazole
Severity: Major
Ibutilide and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong ventricular repolarization. Together they increase the risk of marked QT prolongation and torsades de pointes, which can be fatal.
What this interaction means in plain words
Ibutilide and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ibutilide belongs to Cardiovascular; Posaconazole belongs to Anti Fungals.
Why it happens
Additive pharmacodynamic QTc prolongation through potassium channel blockade.
What to do
Avoid the combination where possible. If ibutilide must be given, ensure continuous ECG monitoring, correct potassium and magnesium, and consider an alternative antifungal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Posaconazole?
MediHelp rates the interaction as major. Ibutilide and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong ventricular repolarization. Together they increase the risk of marked QT prolongation and torsades de pointes, which can be fatal.
How serious is the interaction between Ibutilide and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If ibutilide must be given, ensure continuous ECG monitoring, correct potassium and magnesium, and consider an alternative antifungal.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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