Drug interactions
Icatibant + Ramipril
Severity: Minor
Icatibant and Ramipril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icatibant blocks bradykinin B2 receptors, and bradykinin contributes to some of the effects of ACE inhibitors. Co-administration could theoretically reduce the antihypertensive effect of ramipril. Its use in ACE-inhibitor angioedema is not established as effective, and an interaction in practice is largely theoretical.
What this interaction means in plain words
Icatibant and Ramipril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Icatibant belongs to Miscellaneous; Ramipril belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism through bradykinin B2 receptor blockade, opposing the bradykinin-mediated actions of ACE inhibition.
What to do
Monitor blood pressure during and after icatibant treatment and adjust antihypertensive therapy if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Other interactions of Icatibant
Frequently asked questions
Can I take Icatibant with Ramipril?
MediHelp rates the interaction as minor. Icatibant and Ramipril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icatibant blocks bradykinin B2 receptors, and bradykinin contributes to some of the effects of ACE inhibitors. Co-administration could theoretically reduce the antihypertensive effect of ramipril. Its use in ACE-inhibitor angioedema is not established as effective, and an interaction in practice is largely theoretical.
How serious is the interaction between Icatibant and Ramipril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during and after icatibant treatment and adjust antihypertensive therapy if control is lost.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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