Drug interactions
Icatibant + Trandolapril
Severity: Minor
Icatibant and Trandolapril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icatibant blocks the bradykinin B2 receptor, and part of the blood pressure lowering effect of ACE inhibitors comes from raised bradykinin levels. Concurrent use may therefore reduce the antihypertensive effect of trandolapril. The clinical significance is uncertain and is probably small with short courses of icatibant.
What this interaction means in plain words
Icatibant and Trandolapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Icatibant belongs to Miscellaneous; Trandolapril belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism: icatibant blocks bradykinin B2 receptors, which contribute to the effects of ACE inhibition.
What to do
Monitor blood pressure when icatibant is given to patients on trandolapril. Icatibant is not recommended for ACE inhibitor-induced angioedema, so do not use it for that purpose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Icatibant
Frequently asked questions
Can I take Icatibant with Trandolapril?
MediHelp rates the interaction as minor. Icatibant and Trandolapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icatibant blocks the bradykinin B2 receptor, and part of the blood pressure lowering effect of ACE inhibitors comes from raised bradykinin levels. Concurrent use may therefore reduce the antihypertensive effect of trandolapril. The clinical significance is uncertain and is probably small with short courses of icatibant.
How serious is the interaction between Icatibant and Trandolapril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when icatibant is given to patients on trandolapril. Icatibant is not recommended for ACE inhibitor-induced angioedema, so do not use it for that purpose.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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