Drug interactions
Idelalisib + Itraconazole
Severity: Major
Idelalisib and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole, a strong CYP3A4 inhibitor, increases idelalisib exposure, which may increase hepatotoxicity, diarrhea or colitis, and pneumonitis. Idelalisib is itself a strong CYP3A inhibitor and may raise itraconazole levels.
What this interaction means in plain words
Idelalisib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Idelalisib belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Mutual CYP3A4 inhibition, with itraconazole decreasing idelalisib metabolism.
What to do
Avoid the combination if possible and consider a non-CYP3A-inhibiting antifungal. If used together, monitor liver enzymes and for idelalisib toxicity and itraconazole adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Itraconazole?
MediHelp rates the interaction as major. Idelalisib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole, a strong CYP3A4 inhibitor, increases idelalisib exposure, which may increase hepatotoxicity, diarrhea or colitis, and pneumonitis. Idelalisib is itself a strong CYP3A inhibitor and may raise itraconazole levels.
How serious is the interaction between Idelalisib and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and consider a non-CYP3A-inhibiting antifungal. If used together, monitor liver enzymes and for idelalisib toxicity and itraconazole adverse effects.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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