Drug interactions
Idelalisib + Losartan
Severity: Moderate
Idelalisib and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and may alter losartan's metabolism, increasing parent drug and reducing its more potent active metabolite. The clinical effect on blood pressure is unpredictable but usually modest.
What this interaction means in plain words
Idelalisib and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idelalisib belongs to Oncology; Losartan belongs to Cardiovascular.
Why it happens
Strong CYP3A inhibition by idelalisib reduces losartan metabolic clearance.
What to do
Monitor blood pressure and renal function and adjust the losartan dose if hypotension or loss of effect occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Losartan?
MediHelp rates the interaction as moderate. Idelalisib and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and may alter losartan's metabolism, increasing parent drug and reducing its more potent active metabolite. The clinical effect on blood pressure is unpredictable but usually modest.
How serious is the interaction between Idelalisib and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function and adjust the losartan dose if hypotension or loss of effect occurs.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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