Drug interactions
Idelalisib + Lurasidone
Severity: Contraindicated
Idelalisib and Lurasidone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and is expected to increase lurasidone concentrations markedly. This heightens the risk of dose-related adverse effects including extrapyramidal symptoms and sedation. Strong CYP3A4 inhibitors are contraindicated with lurasidone.
What this interaction means in plain words
Idelalisib and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Idelalisib belongs to Oncology; Lurasidone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lurasidone.
What to do
Avoid concurrent use; consider an alternative antipsychotic while idelalisib is being given.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Lurasidone?
MediHelp rates the interaction as contraindicated. Idelalisib and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Idelalisib is a strong CYP3A inhibitor and is expected to increase lurasidone concentrations markedly. This heightens the risk of dose-related adverse effects including extrapyramidal symptoms and sedation. Strong CYP3A4 inhibitors are contraindicated with lurasidone.
How serious is the interaction between Idelalisib and Lurasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; consider an alternative antipsychotic while idelalisib is being given.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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