Drug interactions
Idelalisib + Norethisterone
Severity: Moderate
Idelalisib and Norethisterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and may increase norethisterone exposure. The likely effect is increased progestogenic adverse effects, and a serious outcome is unlikely at contraceptive doses.
What this interaction means in plain words
Idelalisib and Norethisterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idelalisib belongs to Oncology; Norethisterone belongs to Endocrine.
Why it happens
Idelalisib inhibits CYP3A4, decreasing the metabolism of norethisterone.
What to do
Monitor for progestogenic adverse effects and review the norethisterone dose if they occur. Consider an alternative contraceptive if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Norethisterone?
MediHelp rates the interaction as moderate. Idelalisib and Norethisterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and may increase norethisterone exposure. The likely effect is increased progestogenic adverse effects, and a serious outcome is unlikely at contraceptive doses.
How serious is the interaction between Idelalisib and Norethisterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects and review the norethisterone dose if they occur. Consider an alternative contraceptive if tolerability is poor.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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