Drug interactions
Idelalisib + Saxagliptin
Severity: Moderate
Idelalisib and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and raises saxagliptin exposure. Saxagliptin labeling recommends limiting the dose with strong CYP3A4/5 inhibitors.
What this interaction means in plain words
Idelalisib and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idelalisib belongs to Oncology; Saxagliptin belongs to Endocrine.
Why it happens
Strong inhibition of CYP3A4/5 by idelalisib reduces the metabolism of saxagliptin.
What to do
Limit saxagliptin to 2.5 mg once daily during idelalisib therapy. Monitor glycemic control and for adverse effects such as hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Saxagliptin?
MediHelp rates the interaction as moderate. Idelalisib and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and raises saxagliptin exposure. Saxagliptin labeling recommends limiting the dose with strong CYP3A4/5 inhibitors.
How serious is the interaction between Idelalisib and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit saxagliptin to 2.5 mg once daily during idelalisib therapy. Monitor glycemic control and for adverse effects such as hypoglycemia.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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