Drug interactions
Idelalisib + Solifenacin
Severity: Major
Idelalisib and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A4 inhibitor and can substantially increase solifenacin exposure. This raises the risk of anticholinergic toxicity and QT prolongation.
What this interaction means in plain words
Idelalisib and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Idelalisib belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated metabolism of solifenacin.
What to do
Limit solifenacin to 5 mg daily or less while idelalisib is given. Monitor for anticholinergic effects and consider an alternative agent.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Solifenacin?
MediHelp rates the interaction as major. Idelalisib and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A4 inhibitor and can substantially increase solifenacin exposure. This raises the risk of anticholinergic toxicity and QT prolongation.
How serious is the interaction between Idelalisib and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit solifenacin to 5 mg daily or less while idelalisib is given. Monitor for anticholinergic effects and consider an alternative agent.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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