Drug interactions
Idelalisib + Voriconazole
Severity: Major
Idelalisib and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and may increase idelalisib exposure, raising the risk of hepatotoxicity, diarrhea and other toxicities. Idelalisib is itself a strong CYP3A inhibitor and may raise voriconazole levels.
What this interaction means in plain words
Idelalisib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Idelalisib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Bidirectional CYP3A4 inhibition: voriconazole slows idelalisib metabolism, and idelalisib inhibits voriconazole's CYP3A4 pathway.
What to do
Avoid if possible. If used together, monitor liver enzymes and for idelalisib toxicity, and watch for voriconazole adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Voriconazole?
MediHelp rates the interaction as major. Idelalisib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole inhibits CYP3A4 and may increase idelalisib exposure, raising the risk of hepatotoxicity, diarrhea and other toxicities. Idelalisib is itself a strong CYP3A inhibitor and may raise voriconazole levels.
How serious is the interaction between Idelalisib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used together, monitor liver enzymes and for idelalisib toxicity, and watch for voriconazole adverse effects.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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