Drug interactions
Iloperidone + Melatonin
Severity: Minor
Iloperidone and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is sedating and can cause orthostatic hypotension and somnolence. Melatonin may add to drowsiness and impaired alertness.
What this interaction means in plain words
Iloperidone and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Additive sedative effects.
What to do
Monitor for excess sedation and dizziness, particularly at initiation. Counsel the patient about driving and fall risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Melatonin?
MediHelp rates the interaction as minor. Iloperidone and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is sedating and can cause orthostatic hypotension and somnolence. Melatonin may add to drowsiness and impaired alertness.
How serious is the interaction between Iloperidone and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and dizziness, particularly at initiation. Counsel the patient about driving and fall risk.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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