Drug interactions
Iloperidone + Methamphetamine
Severity: Moderate
Iloperidone and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a sedating antipsychotic and methamphetamine is a stimulant that can aggravate psychosis. Stimulant use may counteract the antipsychotic effect and worsen psychotic symptoms, and both drugs can affect heart rate and rhythm.
What this interaction means in plain words
Iloperidone and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Opposing dopaminergic pharmacodynamics (D2 antagonism versus dopamine release); iloperidone also prolongs QT.
What to do
Monitor for worsening psychosis and consider an ECG if other QT-prolonging risk factors are present. Avoid stimulants in patients with active psychosis if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Methamphetamine?
MediHelp rates the interaction as moderate. Iloperidone and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is a sedating antipsychotic and methamphetamine is a stimulant that can aggravate psychosis. Stimulant use may counteract the antipsychotic effect and worsen psychotic symptoms, and both drugs can affect heart rate and rhythm.
How serious is the interaction between Iloperidone and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for worsening psychosis and consider an ECG if other QT-prolonging risk factors are present. Avoid stimulants in patients with active psychosis if possible.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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