Drug interactions
Iloperidone + Methylprednisolone
Severity: Minor
Iloperidone and Methylprednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak CYP3A inhibitor and may slightly increase methylprednisolone exposure. The clinical effect is generally small.
What this interaction means in plain words
Iloperidone and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Methylprednisolone belongs to Endocrine.
Why it happens
Weak inhibition of CYP3A4 by iloperidone reduces methylprednisolone clearance.
What to do
No dose change is generally needed; monitor for steroid adverse effects during prolonged high-dose therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Methylprednisolone?
MediHelp rates the interaction as minor. Iloperidone and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is a weak CYP3A inhibitor and may slightly increase methylprednisolone exposure. The clinical effect is generally small.
How serious is the interaction between Iloperidone and Methylprednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for steroid adverse effects during prolonged high-dose therapy.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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