Drug interactions
Iloperidone + Miglitol
Severity: Moderate
Iloperidone and Miglitol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics, including iloperidone, are associated with hyperglycemia and altered glucose control, though iloperidone has a relatively modest metabolic effect. This may reduce the effectiveness of miglitol.
What this interaction means in plain words
Iloperidone and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Miglitol belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through antipsychotic-related insulin resistance and impaired glucose regulation.
What to do
Monitor fasting glucose and HbA1c at baseline and periodically during treatment. Intensify antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Miglitol
- Miglitol + Pramlintide Major
- Aripiprazole + Miglitol Moderate
- Asenapine + Miglitol Moderate
- Chlorthalidone + Miglitol Moderate
- Clozapine + Miglitol Moderate
- Cortisone + Miglitol Moderate
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Miglitol?
MediHelp rates the interaction as moderate. Iloperidone and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics, including iloperidone, are associated with hyperglycemia and altered glucose control, though iloperidone has a relatively modest metabolic effect. This may reduce the effectiveness of miglitol.
How serious is the interaction between Iloperidone and Miglitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c at baseline and periodically during treatment. Intensify antidiabetic therapy if control worsens.
What other medicines interact with Miglitol?
MediHelp also lists interactions of Miglitol with, for example, Pramlintide, Aripiprazole, Asenapine. The full list is on the Miglitol page.
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