Drug interactions
Iloperidone + Modafinil
Severity: Moderate
Iloperidone and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is sedating and opposes modafinil's wakefulness effects. Iloperidone's CYP3A4 inhibition may modestly raise modafinil exposure, and modafinil's CYP3A4 induction may lower iloperidone levels. Iloperidone also prolongs the QT interval.
What this interaction means in plain words
Iloperidone and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Opposing CNS effects plus bidirectional CYP3A4 modulation (iloperidone inhibition, modafinil induction).
What to do
Monitor clinical response to both drugs and for adverse effects such as tachycardia or QT-related symptoms; adjust doses as clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Modafinil?
MediHelp rates the interaction as moderate. Iloperidone and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is sedating and opposes modafinil's wakefulness effects. Iloperidone's CYP3A4 inhibition may modestly raise modafinil exposure, and modafinil's CYP3A4 induction may lower iloperidone levels. Iloperidone also prolongs the QT interval.
How serious is the interaction between Iloperidone and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to both drugs and for adverse effects such as tachycardia or QT-related symptoms; adjust doses as clinically indicated.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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