Drug interactions
Iloperidone + Ruxolitinib
Severity: Minor
Iloperidone and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone may inhibit CYP3A4 and could increase ruxolitinib levels, but the effect is expected to be modest. Increased ruxolitinib exposure may worsen cytopenias.
What this interaction means in plain words
Iloperidone and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Ruxolitinib belongs to Oncology.
Why it happens
Iloperidone weakly inhibits CYP3A4 metabolism of ruxolitinib.
What to do
Monitor blood counts as routinely scheduled and adjust ruxolitinib if cytopenias emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Iloperidone and Ruxolitinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ruxolitinib
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Ruxolitinib?
MediHelp rates the interaction as minor. Iloperidone and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone may inhibit CYP3A4 and could increase ruxolitinib levels, but the effect is expected to be modest. Increased ruxolitinib exposure may worsen cytopenias.
How serious is the interaction between Iloperidone and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts as routinely scheduled and adjust ruxolitinib if cytopenias emerge.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
