Drug interactions
Iloperidone + Sotalol
Severity: Major
Iloperidone and Sotalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is an antipsychotic that prolongs the QT interval and its labeling advises against use with other QT-prolonging drugs. Adding sotalol raises the risk of torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Iloperidone and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Iloperidone belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic QT prolongation through potassium channel blockade.
What to do
Avoid the combination; choose an antipsychotic with less QT effect or a different antiarrhythmic. If unavoidable, monitor ECG and keep potassium and magnesium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Sotalol?
MediHelp rates the interaction as major. Iloperidone and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iloperidone is an antipsychotic that prolongs the QT interval and its labeling advises against use with other QT-prolonging drugs. Adding sotalol raises the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Iloperidone and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; choose an antipsychotic with less QT effect or a different antiarrhythmic. If unavoidable, monitor ECG and keep potassium and magnesium normal.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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