Drug interactions
Iloperidone + Temsirolimus
Severity: Minor
Iloperidone and Temsirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has been described as a time-dependent CYP3A inhibitor, so it could raise exposure to temsirolimus and its active metabolite sirolimus. Higher levels may worsen mucositis, cytopenias, hyperglycemia, and other mTOR-related adverse effects.
What this interaction means in plain words
Iloperidone and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Temsirolimus belongs to Oncology.
Why it happens
Possible weak inhibition of CYP3A4-mediated metabolism of temsirolimus and sirolimus by iloperidone.
What to do
No empirical dose change is needed; monitor for temsirolimus toxicity such as stomatitis, cytopenias, and hyperglycemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Temsirolimus?
MediHelp rates the interaction as minor. Iloperidone and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone has been described as a time-dependent CYP3A inhibitor, so it could raise exposure to temsirolimus and its active metabolite sirolimus. Higher levels may worsen mucositis, cytopenias, hyperglycemia, and other mTOR-related adverse effects.
How serious is the interaction between Iloperidone and Temsirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for temsirolimus toxicity such as stomatitis, cytopenias, and hyperglycemia.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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