Drug interactions
Iloperidone + Tiotropium-olodaterol
Severity: Moderate
Iloperidone and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone prolongs the QT interval and has some anticholinergic activity, while olodaterol may add arrhythmic risk through hypokalemia and tachycardia. Anticholinergic effects may also add to those of tiotropium.
What this interaction means in plain words
Iloperidone and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta2-agonist cardiac effects, plus additive antimuscarinic activity.
What to do
Check ECG and electrolytes at baseline and when doses change. Monitor for anticholinergic effects such as constipation and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Iloperidone and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone prolongs the QT interval and has some anticholinergic activity, while olodaterol may add arrhythmic risk through hypokalemia and tachycardia. Anticholinergic effects may also add to those of tiotropium.
How serious is the interaction between Iloperidone and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and when doses change. Monitor for anticholinergic effects such as constipation and urinary retention.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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