Drug interactions
Iloperidone + Trazodone
Severity: Major
Iloperidone and Trazodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combining them raises the risk of torsades de pointes. Additive sedation and orthostatic hypotension may also occur, and iloperidone's weak CYP3A4 inhibition may modestly raise trazodone exposure.
What this interaction means in plain words
Iloperidone and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Iloperidone belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and CNS depression, with possible CYP3A4 inhibition by iloperidone reducing trazodone clearance.
What to do
Avoid the combination where possible; if it is necessary, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc and blood pressure. Consider a lower trazodone dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Trazodone?
MediHelp rates the interaction as major. Iloperidone and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combining them raises the risk of torsades de pointes. Additive sedation and orthostatic hypotension may also occur, and iloperidone's weak CYP3A4 inhibition may modestly raise trazodone exposure.
How serious is the interaction between Iloperidone and Trazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is necessary, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc and blood pressure. Consider a lower trazodone dose.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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