Drug interactions
Iloperidone + Zonisamide
Severity: Minor
Iloperidone and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone may weakly inhibit CYP3A4 and could raise zonisamide levels slightly. Both drugs also cause somnolence and dizziness, so combined sedation is plausible.
What this interaction means in plain words
Iloperidone and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Zonisamide belongs to Central Nervous System.
Why it happens
Possible CYP3A4 inhibition by iloperidone, plus additive sedative effects.
What to do
Monitor for drowsiness and dizziness after starting the combination. Adjust zonisamide dose only if adverse effects develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Zonisamide?
MediHelp rates the interaction as minor. Iloperidone and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone may weakly inhibit CYP3A4 and could raise zonisamide levels slightly. Both drugs also cause somnolence and dizziness, so combined sedation is plausible.
How serious is the interaction between Iloperidone and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and dizziness after starting the combination. Adjust zonisamide dose only if adverse effects develop.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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