Drug interactions
Iloprost + Ropivacaine
Severity: Moderate
Iloprost and Ropivacaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost is a potent vasodilator that lowers blood pressure, particularly when given intravenously. Ropivacaine, especially when used for epidural or spinal block, can cause sympathetic blockade and hypotension, so the hypotensive effects may add together.
What this interaction means in plain words
Iloprost and Ropivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Ropivacaine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotension from prostacyclin-mediated vasodilation and local anesthetic-induced sympathetic blockade.
What to do
Monitor blood pressure closely when neuraxial or large-dose ropivacaine is used with iloprost, and be prepared to give fluids or vasopressors. Reduce the iloprost dose if hypotension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropivacaine
- Bupivacaine implant + Ropivacaine Major
- Bupivacaine liposome + Ropivacaine Major
- Amlodipine-benazepril + Ropivacaine Moderate
- Benazepril + Ropivacaine Moderate
- Captopril-hydrochlorothiazide + Ropivacaine Moderate
- Captopril + Ropivacaine Moderate
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Ropivacaine?
MediHelp rates the interaction as moderate. Iloprost and Ropivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloprost is a potent vasodilator that lowers blood pressure, particularly when given intravenously. Ropivacaine, especially when used for epidural or spinal block, can cause sympathetic blockade and hypotension, so the hypotensive effects may add together.
How serious is the interaction between Iloprost and Ropivacaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely when neuraxial or large-dose ropivacaine is used with iloprost, and be prepared to give fluids or vasopressors. Reduce the iloprost dose if hypotension persists.
What other medicines interact with Ropivacaine?
MediHelp also lists interactions of Ropivacaine with, for example, Bupivacaine implant, Bupivacaine liposome, Amlodipine-benazepril. The full list is on the Ropivacaine page.
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