Drug interactions
Iloprost + Sevoflurane
Severity: Moderate
Iloprost and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost is a prostacyclin analogue that causes vasodilation, and sevoflurane also lowers vascular resistance and blood pressure. Used together, hypotension may be more pronounced, particularly with intravenous iloprost.
What this interaction means in plain words
Iloprost and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive vasodilatory and hypotensive pharmacodynamic effects.
What to do
Monitor blood pressure continuously during anesthesia and treat hypotension with fluids or vasopressors. Reduce the iloprost infusion rate if hypotension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Sevoflurane?
MediHelp rates the interaction as moderate. Iloprost and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloprost is a prostacyclin analogue that causes vasodilation, and sevoflurane also lowers vascular resistance and blood pressure. Used together, hypotension may be more pronounced, particularly with intravenous iloprost.
How serious is the interaction between Iloprost and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during anesthesia and treat hypotension with fluids or vasopressors. Reduce the iloprost infusion rate if hypotension persists.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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