Drug interactions
Iloprost + Sotalol
Severity: Moderate
Iloprost and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost is a vasodilator that can lower blood pressure, and sotalol can add to the hypotension and bradycardia. The risk is most relevant with intravenous iloprost.
What this interaction means in plain words
Iloprost and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from prostacyclin vasodilation and beta-blockade.
What to do
Monitor blood pressure and heart rate when initiating or adjusting iloprost, and reduce the iloprost dose if hypotension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Sotalol?
MediHelp rates the interaction as moderate. Iloprost and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloprost is a vasodilator that can lower blood pressure, and sotalol can add to the hypotension and bradycardia. The risk is most relevant with intravenous iloprost.
How serious is the interaction between Iloprost and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when initiating or adjusting iloprost, and reduce the iloprost dose if hypotension persists.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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