Drug interactions
Imatinib + Liothyronine
Severity: Moderate
Imatinib and Liothyronine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause hypothyroidism and increase thyroid hormone requirements in patients on replacement, especially after thyroidectomy. Replacement doses may become inadequate.
What this interaction means in plain words
Imatinib and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Liothyronine belongs to Endocrine.
Why it happens
Imatinib likely increases thyroid hormone clearance and may impair thyroid function; the mechanism is not fully established.
What to do
Monitor TSH regularly after starting imatinib. Increase the liothyronine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Liothyronine?
MediHelp rates the interaction as moderate. Imatinib and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause hypothyroidism and increase thyroid hormone requirements in patients on replacement, especially after thyroidectomy. Replacement doses may become inadequate.
How serious is the interaction between Imatinib and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor TSH regularly after starting imatinib. Increase the liothyronine dose as needed.
What other medicines interact with Liothyronine?
MediHelp also lists interactions of Liothyronine with, for example, Alogliptin-metformin, Amitriptyline, Amobarbital. The full list is on the Liothyronine page.
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