Drug interactions
Imatinib + Medroxyprogesterone
Severity: Minor
Imatinib and Medroxyprogesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 and could modestly raise progestin concentrations. Clinically significant effects are unlikely, and the main consideration is possible increased progestogenic adverse effects.
What this interaction means in plain words
Imatinib and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Medroxyprogesterone belongs to Endocrine.
Why it happens
Imatinib weakly inhibits CYP3A4, which may reduce the metabolism of medroxyprogesterone.
What to do
No dose change is usually needed; monitor for increased progestogenic effects such as fluid retention, bleeding changes or mood effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Medroxyprogesterone
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Medroxyprogesterone?
MediHelp rates the interaction as minor. Imatinib and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib inhibits CYP3A4 and could modestly raise progestin concentrations. Clinically significant effects are unlikely, and the main consideration is possible increased progestogenic adverse effects.
How serious is the interaction between Imatinib and Medroxyprogesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for increased progestogenic effects such as fluid retention, bleeding changes or mood effects.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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