Drug interactions
Imatinib + Posaconazole
Severity: Moderate
Imatinib and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can raise imatinib concentrations because imatinib is mainly metabolised by CYP3A4. Higher exposure may increase fluid retention, myelosuppression, hepatotoxicity and QT effects.
What this interaction means in plain words
Imatinib and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 reduces imatinib metabolism.
What to do
Monitor blood counts, liver function, fluid status and ECG, and reduce imatinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Posaconazole?
MediHelp rates the interaction as moderate. Imatinib and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole can raise imatinib concentrations because imatinib is mainly metabolised by CYP3A4. Higher exposure may increase fluid retention, myelosuppression, hepatotoxicity and QT effects.
How serious is the interaction between Imatinib and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, liver function, fluid status and ECG, and reduce imatinib dose if toxicity develops.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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