Drug interactions
Imatinib + Prochlorperazine
Severity: Moderate
Imatinib and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6 and may raise prochlorperazine levels. Both drugs can prolong the QT interval, so combined use may increase arrhythmia risk.
What this interaction means in plain words
Imatinib and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Prochlorperazine belongs to Central Nervous System.
Why it happens
Imatinib inhibits CYP2D6, and both drugs may prolong QT additively.
What to do
Monitor the ECG and electrolytes in patients with other QT risk factors. Watch for sedation and extrapyramidal symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Prochlorperazine?
MediHelp rates the interaction as moderate. Imatinib and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP2D6 and may raise prochlorperazine levels. Both drugs can prolong the QT interval, so combined use may increase arrhythmia risk.
How serious is the interaction between Imatinib and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and electrolytes in patients with other QT risk factors. Watch for sedation and extrapyramidal symptoms.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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