Drug interactions
Imatinib + Talazoparib
Severity: Moderate
Imatinib and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may inhibit BCRP and thereby increase talazoparib exposure. This may increase hematologic toxicity such as anemia, neutropenia and thrombocytopenia.
What this interaction means in plain words
Imatinib and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Talazoparib belongs to Oncology.
Why it happens
Inhibition of BCRP-mediated efflux of talazoparib increases its systemic exposure.
What to do
Monitor blood counts closely during coadministration and reduce the talazoparib dose or interrupt it if toxicity occurs. Consider an alternative to imatinib where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Imatinib with Talazoparib?
MediHelp rates the interaction as moderate. Imatinib and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may inhibit BCRP and thereby increase talazoparib exposure. This may increase hematologic toxicity such as anemia, neutropenia and thrombocytopenia.
How serious is the interaction between Imatinib and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely during coadministration and reduce the talazoparib dose or interrupt it if toxicity occurs. Consider an alternative to imatinib where possible.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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