Drug interactions
Imatinib + Tasimelteon
Severity: Minor
Imatinib and Tasimelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tasimelteon is metabolized by CYP3A4 and CYP1A2, and imatinib is a moderate CYP3A4 inhibitor. Tasimelteon exposure may rise, causing more somnolence, headache or dizziness.
What this interaction means in plain words
Imatinib and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Tasimelteon belongs to Central Nervous System.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of tasimelteon.
What to do
Monitor for excess sedation and other adverse effects; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Tasimelteon
Frequently asked questions
Can I take Imatinib with Tasimelteon?
MediHelp rates the interaction as minor. Imatinib and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tasimelteon is metabolized by CYP3A4 and CYP1A2, and imatinib is a moderate CYP3A4 inhibitor. Tasimelteon exposure may rise, causing more somnolence, headache or dizziness.
How serious is the interaction between Imatinib and Tasimelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and other adverse effects; no routine dose change is needed.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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