Drug interactions
Imatinib + Tepotinib
Severity: Moderate
Imatinib and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and may raise imatinib concentrations modestly. Increased imatinib exposure could worsen fluid retention, cytopenias and gastrointestinal effects.
What this interaction means in plain words
Imatinib and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibits P-gp efflux of imatinib, which is a P-gp substrate, increasing exposure.
What to do
Monitor for imatinib toxicity including blood counts, edema and liver tests. Reduce the imatinib dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Imatinib with Tepotinib?
MediHelp rates the interaction as moderate. Imatinib and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein and may raise imatinib concentrations modestly. Increased imatinib exposure could worsen fluid retention, cytopenias and gastrointestinal effects.
How serious is the interaction between Imatinib and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imatinib toxicity including blood counts, edema and liver tests. Reduce the imatinib dose if adverse effects emerge.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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