Drug interactions
Indacaterol + Itraconazole
Severity: Moderate
Indacaterol and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can prolong QT and inhibits CYP3A4 and P-gp, which may modestly raise indacaterol exposure. Combined effects may increase tachycardia, hypokalemia and arrhythmia risk.
What this interaction means in plain words
Indacaterol and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Itraconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation plus inhibition of CYP3A4/P-gp-mediated indacaterol clearance.
What to do
Monitor heart rate, ECG and potassium, especially in patients with cardiac disease; consider alternative antifungal if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Indacaterol with Itraconazole?
MediHelp rates the interaction as moderate. Indacaterol and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole can prolong QT and inhibits CYP3A4 and P-gp, which may modestly raise indacaterol exposure. Combined effects may increase tachycardia, hypokalemia and arrhythmia risk.
How serious is the interaction between Indacaterol and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium, especially in patients with cardiac disease; consider alternative antifungal if QTc lengthens.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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