Drug interactions
Indacaterol + Metoprolol
Severity: Moderate
Indacaterol and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers antagonize the bronchodilator effect of beta-2 agonists and may provoke bronchospasm in patients with airway disease. The effect is less likely with cardioselective agents but can still occur.
What this interaction means in plain words
Indacaterol and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Metoprolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta-2 receptors; metoprolol is beta-1 selective, so effect is dose-dependent.
What to do
Use the lowest effective dose of a cardioselective beta-blocker only when needed, and monitor respiratory symptoms and lung function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Indacaterol with Metoprolol?
MediHelp rates the interaction as moderate. Indacaterol and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers antagonize the bronchodilator effect of beta-2 agonists and may provoke bronchospasm in patients with airway disease. The effect is less likely with cardioselective agents but can still occur.
How serious is the interaction between Indacaterol and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of a cardioselective beta-blocker only when needed, and monitor respiratory symptoms and lung function.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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