Drug interactions
Indacaterol + Osilodrostat
Severity: Moderate
Indacaterol and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval, and indacaterol may add to this and lower potassium. The combination may increase arrhythmia risk, especially if hypokalemia is present.
What this interaction means in plain words
Indacaterol and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia as a possible contributor.
What to do
Obtain ECG at baseline and during treatment, and correct potassium and magnesium. Reassess therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Osilodrostat
Frequently asked questions
Can I take Indacaterol with Osilodrostat?
MediHelp rates the interaction as moderate. Indacaterol and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat can prolong the QT interval, and indacaterol may add to this and lower potassium. The combination may increase arrhythmia risk, especially if hypokalemia is present.
How serious is the interaction between Indacaterol and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG at baseline and during treatment, and correct potassium and magnesium. Reassess therapy if QTc becomes markedly prolonged.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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