Drug interactions
Indacaterol + Osimertinib
Severity: Moderate
Indacaterol and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QT interval, and indacaterol may add to this effect and lower potassium. This may raise the risk of ventricular arrhythmias in patients with other risk factors.
What this interaction means in plain words
Indacaterol and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Osimertinib belongs to Oncology.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia as a possible contributor.
What to do
Monitor ECG and electrolytes periodically, and correct potassium and magnesium abnormalities. Follow osimertinib labeling for management if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Osimertinib
Frequently asked questions
Can I take Indacaterol with Osimertinib?
MediHelp rates the interaction as moderate. Indacaterol and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong the QT interval, and indacaterol may add to this effect and lower potassium. This may raise the risk of ventricular arrhythmias in patients with other risk factors.
How serious is the interaction between Indacaterol and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes periodically, and correct potassium and magnesium abnormalities. Follow osimertinib labeling for management if QTc becomes markedly prolonged.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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