Drug interactions
Indacaterol + Perphenazine
Severity: Moderate
Indacaterol and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine can prolong the QT interval and indacaterol may add to this through sympathomimetic and potassium-lowering effects. The combination may increase the chance of ventricular arrhythmias, especially with other risk factors.
What this interaction means in plain words
Indacaterol and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization, with beta-2 agonist-related hypokalemia.
What to do
Monitor ECG and QTc in patients with cardiac risk factors. Keep potassium and magnesium within normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Indacaterol with Perphenazine?
MediHelp rates the interaction as moderate. Indacaterol and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine can prolong the QT interval and indacaterol may add to this through sympathomimetic and potassium-lowering effects. The combination may increase the chance of ventricular arrhythmias, especially with other risk factors.
How serious is the interaction between Indacaterol and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and QTc in patients with cardiac risk factors. Keep potassium and magnesium within normal range.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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