Drug interactions
Indacaterol + Ribociclib
Severity: Major
Indacaterol and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib causes concentration-dependent QT prolongation, and indacaterol may add arrhythmic risk through tachycardia and hypokalemia. Ribociclib also inhibits CYP3A4 and may modestly increase indacaterol exposure.
What this interaction means in plain words
Indacaterol and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol belongs to Respiratory; Ribociclib belongs to Oncology.
Why it happens
Additive QT prolongation with beta-agonist effects and CYP3A4 inhibition by ribociclib.
What to do
Monitor ECG and electrolytes at baseline and during ribociclib treatment, and consider an alternative bronchodilator if QTc prolongs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Indacaterol with Ribociclib?
MediHelp rates the interaction as major. Indacaterol and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib causes concentration-dependent QT prolongation, and indacaterol may add arrhythmic risk through tachycardia and hypokalemia. Ribociclib also inhibits CYP3A4 and may modestly increase indacaterol exposure.
How serious is the interaction between Indacaterol and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and during ribociclib treatment, and consider an alternative bronchodilator if QTc prolongs.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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