Drug interactions
Indacaterol-glycopyrronium + Levoketoconazole
Severity: Moderate
Indacaterol-glycopyrronium and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a potent CYP3A4 and P-gp inhibitor that can raise systemic indacaterol exposure. Levoketoconazole also prolongs the QT interval, so beta-agonist cardiac effects may be more significant.
What this interaction means in plain words
Indacaterol-glycopyrronium and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 and P-gp reduces indacaterol clearance, with additive QT effects.
What to do
No dose adjustment is usually needed at the standard inhaled dose, but monitor heart rate, potassium and QTc, particularly in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Levoketoconazole?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a potent CYP3A4 and P-gp inhibitor that can raise systemic indacaterol exposure. Levoketoconazole also prolongs the QT interval, so beta-agonist cardiac effects may be more significant.
How serious is the interaction between Indacaterol-glycopyrronium and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed at the standard inhaled dose, but monitor heart rate, potassium and QTc, particularly in patients with cardiac risk factors.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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