Drug interactions
Indacaterol-glycopyrronium + Lopinavir
Severity: Moderate
Indacaterol-glycopyrronium and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir can prolong the QT interval and the ritonavir component strongly inhibits CYP3A4 and P-gp, which may raise indacaterol exposure. Together this increases the likelihood of beta-agonist cardiac effects.
What this interaction means in plain words
Indacaterol-glycopyrronium and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Lopinavir belongs to Anti Virals.
Why it happens
CYP3A4/P-gp inhibition raises indacaterol levels, with additive effects on cardiac repolarisation.
What to do
Monitor heart rate, potassium and ECG in patients with cardiac risk factors. No dose change is usually required at standard inhaled doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Lopinavir?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir can prolong the QT interval and the ritonavir component strongly inhibits CYP3A4 and P-gp, which may raise indacaterol exposure. Together this increases the likelihood of beta-agonist cardiac effects.
How serious is the interaction between Indacaterol-glycopyrronium and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, potassium and ECG in patients with cardiac risk factors. No dose change is usually required at standard inhaled doses.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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