Drug interactions
Indacaterol-glycopyrronium + Methylprednisolone
Severity: Moderate
Indacaterol-glycopyrronium and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol may lower serum potassium and systemic corticosteroids can promote potassium loss. Combined use may cause hypokalemia, mainly with high-dose or prolonged steroid courses.
What this interaction means in plain words
Indacaterol-glycopyrronium and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Methylprednisolone belongs to Endocrine.
Why it happens
Additive hypokalemia from beta-2 agonist potassium shift and corticosteroid renal potassium loss.
What to do
Monitor serum potassium during systemic methylprednisolone therapy, especially in severe COPD exacerbations. Supplement potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Methylprednisolone?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol may lower serum potassium and systemic corticosteroids can promote potassium loss. Combined use may cause hypokalemia, mainly with high-dose or prolonged steroid courses.
How serious is the interaction between Indacaterol-glycopyrronium and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during systemic methylprednisolone therapy, especially in severe COPD exacerbations. Supplement potassium as needed.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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