Drug interactions
Indacaterol-glycopyrronium + Metolazone
Severity: Moderate
Indacaterol-glycopyrronium and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone is a potent thiazide-like diuretic that causes marked potassium and magnesium loss. With indacaterol, hypokalemia may be worsened and can trigger arrhythmias.
What this interaction means in plain words
Indacaterol-glycopyrronium and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Metolazone belongs to Cardiovascular.
Why it happens
Additive hypokalemia from beta-2 agonist potassium shift and diuretic-induced renal potassium wasting.
What to do
Monitor serum potassium and magnesium regularly and replace deficits. Take extra care in patients with heart failure or on digoxin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Metolazone
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Metolazone?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone is a potent thiazide-like diuretic that causes marked potassium and magnesium loss. With indacaterol, hypokalemia may be worsened and can trigger arrhythmias.
How serious is the interaction between Indacaterol-glycopyrronium and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and replace deficits. Take extra care in patients with heart failure or on digoxin.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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