Drug interactions
Indacaterol-glycopyrronium + Ondansetron
Severity: Moderate
Indacaterol-glycopyrronium and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ondansetron prolongs the QT interval in a dose-dependent manner, and beta-2 agonists such as indacaterol may cause hypokalemia and QT changes. Combined use may increase the risk of torsades de pointes, especially with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Indacaterol-glycopyrronium and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation, with beta-2 agonist-related hypokalemia.
What to do
Use the lowest effective ondansetron dose and check potassium and magnesium. Obtain an ECG in patients with heart failure, bradyarrhythmia or other QT-prolonging drugs, and avoid in congenital long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Ondansetron?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ondansetron prolongs the QT interval in a dose-dependent manner, and beta-2 agonists such as indacaterol may cause hypokalemia and QT changes. Combined use may increase the risk of torsades de pointes, especially with electrolyte disturbances or cardiac disease.
How serious is the interaction between Indacaterol-glycopyrronium and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective ondansetron dose and check potassium and magnesium. Obtain an ECG in patients with heart failure, bradyarrhythmia or other QT-prolonging drugs, and avoid in congenital long QT syndrome.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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