Drug interactions
Indacaterol-glycopyrronium + Ozanimod
Severity: Moderate
Indacaterol-glycopyrronium and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and affect conduction at initiation, while indacaterol may prolong the QTc interval. Together they could increase the risk of arrhythmia, particularly in patients who also take other QT-prolonging drugs or have underlying cardiac disease.
What this interaction means in plain words
Indacaterol-glycopyrronium and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Ozanimod belongs to Central Nervous System.
Why it happens
Additive cardiac effects: ozanimod-induced bradycardia combined with beta-agonist-related QT prolongation and possible hypokalemia.
What to do
Review the ECG before starting ozanimod and seek cardiology advice in patients with QT risk factors. Monitor heart rate and QTc and keep potassium within the normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Ozanimod?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and affect conduction at initiation, while indacaterol may prolong the QTc interval. Together they could increase the risk of arrhythmia, particularly in patients who also take other QT-prolonging drugs or have underlying cardiac disease.
How serious is the interaction between Indacaterol-glycopyrronium and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the ECG before starting ozanimod and seek cardiology advice in patients with QT risk factors. Monitor heart rate and QTc and keep potassium within the normal range.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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