Drug interactions
Indacaterol-glycopyrronium + Panobinostat
Severity: Major
Indacaterol-glycopyrronium and Panobinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat prolongs the QT interval, and its labeling advises against use with other QT-prolonging drugs. Indacaterol may contribute through beta-adrenergic effects and hypokalemia, raising the risk of torsades de pointes.
What this interaction means in plain words
Indacaterol-glycopyrronium and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol-glycopyrronium belongs to Respiratory; Panobinostat belongs to Oncology.
Why it happens
Additive QT prolongation, with possible beta-agonist-induced hypokalemia.
What to do
Avoid the combination where possible and use a non-QT-prolonging bronchodilator. If it cannot be avoided, monitor ECG and keep potassium and magnesium in the normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Panobinostat?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Panobinostat prolongs the QT interval, and its labeling advises against use with other QT-prolonging drugs. Indacaterol may contribute through beta-adrenergic effects and hypokalemia, raising the risk of torsades de pointes.
How serious is the interaction between Indacaterol-glycopyrronium and Panobinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use a non-QT-prolonging bronchodilator. If it cannot be avoided, monitor ECG and keep potassium and magnesium in the normal range.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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