Drug interactions
Indacaterol-glycopyrronium + Ranolazine
Severity: Moderate
Indacaterol-glycopyrronium and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine causes dose-related QT prolongation, and indacaterol may add to this effect. Ranolazine also inhibits P-gp, which may modestly raise exposure to some co-administered drugs.
What this interaction means in plain words
Indacaterol-glycopyrronium and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Ranolazine belongs to Cardiovascular.
Why it happens
Additive QT prolongation; possible P-gp inhibition.
What to do
Monitor ECG and keep potassium and magnesium normal. Watch for palpitations or syncope and reassess therapy if QTc increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Ranolazine?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine causes dose-related QT prolongation, and indacaterol may add to this effect. Ranolazine also inhibits P-gp, which may modestly raise exposure to some co-administered drugs.
How serious is the interaction between Indacaterol-glycopyrronium and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium and magnesium normal. Watch for palpitations or syncope and reassess therapy if QTc increases.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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