Drug interactions
Indacaterol-glycopyrronium + Risperidone
Severity: Moderate
Indacaterol-glycopyrronium and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can prolong the QT interval, and indacaterol, a beta2-agonist, may add to this effect and to hypokalemia-related arrhythmia risk. Risperidone has modest anticholinergic activity that may add to glycopyrronium effects, though systemic glycopyrronium exposure is low.
What this interaction means in plain words
Indacaterol-glycopyrronium and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and beta2-mediated hypokalemia, plus minor additive anticholinergic effects.
What to do
Check baseline ECG and potassium in patients with QT risk factors, and correct electrolyte abnormalities. Monitor for palpitations, syncope and anticholinergic effects such as urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Risperidone?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can prolong the QT interval, and indacaterol, a beta2-agonist, may add to this effect and to hypokalemia-related arrhythmia risk. Risperidone has modest anticholinergic activity that may add to glycopyrronium effects, though systemic glycopyrronium exposure is low.
How serious is the interaction between Indacaterol-glycopyrronium and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and potassium in patients with QT risk factors, and correct electrolyte abnormalities. Monitor for palpitations, syncope and anticholinergic effects such as urinary retention.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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