Drug interactions
Indacaterol-glycopyrronium + Sotalol
Severity: Major
Indacaterol-glycopyrronium and Sotalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is a nonselective beta-blocker that directly opposes the bronchodilating effect of indacaterol and can precipitate severe bronchospasm in patients with COPD or asthma. Sotalol also prolongs the QT interval, and beta2-agonist-induced hypokalemia can raise the arrhythmia risk.
What this interaction means in plain words
Indacaterol-glycopyrronium and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol-glycopyrronium belongs to Respiratory; Sotalol belongs to Cardiovascular.
Why it happens
Beta2-receptor antagonism opposes beta2-agonist bronchodilation, with additive QT and hypokalemia risk.
What to do
Avoid sotalol in patients with obstructive airway disease where possible and choose an alternative antiarrhythmic. If it cannot be avoided, monitor respiratory function, ECG and potassium closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Sotalol?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol is a nonselective beta-blocker that directly opposes the bronchodilating effect of indacaterol and can precipitate severe bronchospasm in patients with COPD or asthma. Sotalol also prolongs the QT interval, and beta2-agonist-induced hypokalemia can raise the arrhythmia risk.
How serious is the interaction between Indacaterol-glycopyrronium and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid sotalol in patients with obstructive airway disease where possible and choose an alternative antiarrhythmic. If it cannot be avoided, monitor respiratory function, ECG and potassium closely.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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